49ers Lions 2025r. The san francisco 49ers may have an extremely easy schedule in 2025 based on their projected opponents. View results for regular season and postseason games between the detroit lions and san francisco 49ers.
The san francisco 49ers’ week 17 loss to the detroit lions officially locked the team into last place in the nfc west, regardless of the outcome of their week 18 matchup against the. New york giants shedeur sanders | qb | colorado.